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Regulation of nitrogen metabolism in Mycobacterium tuberculosis : A comparison with mechanisms in Corynebacterium glutamicum and Streptomyces coelicolor
Author(s) -
Harper Catriona,
Hayward Don,
Wiid Ian,
van Helden Paul
Publication year - 2008
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.100
Subject(s) - corynebacterium glutamicum , streptomyces coelicolor , mycobacterium tuberculosis , corynebacterium , microbiology and biotechnology , biology , biochemistry , streptomyces , mycobacterium , bacteria , metabolism , tuberculosis , genetics , medicine , pathology
The mechanisms governing the regulation of nitrogen metabolism in Corynebacterium glutamicum and Streptomyces coelicolor have been extensively studied. These Actinomycetales are closely related to the Mycobacterium genus and may therefore serve as a models to elucidate the cascade of nitrogen signalling in other mycobacteria. Some factors involved in nitrogen metabolism in Mycobacterium tuberculosis have been described, including glutamine synthetase and its adenylyltransferase, but not much data concerning the other components involved in the signalling cascade is available. In this review a comparative study of factors involved in nitrogen metabolism in C . glutamicum and S. coelicolor is made to identify similarities with M. tuberculosis on both a genomic and proteomic level. This may provide insight into a potential global mechanism of nitrogen control in Mycobacterium tuberculosis . © 2008 IUBMB IUBMB Life, 60(10): 643–650, 2008