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The kinetics of 18 f‐fluorodeoxyglucose uptake in the choroid plexus
Author(s) -
RmeilyHaddad Mireille,
Balédent Olivier,
StoquartElSankari Souraya,
Sérot JeanMarie,
Bailly Pascal,
Meyer MarcEtienne
Publication year - 2011
Publication title -
international journal of imaging systems and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.359
H-Index - 47
eISSN - 1098-1098
pISSN - 0899-9457
DOI - 10.1002/ima.20264
Subject(s) - choroid plexus , cerebrospinal fluid , positron emission tomography , fluorodeoxyglucose , nuclear medicine , in vivo , voxel , kinetics , population , chemistry , medicine , pathology , central nervous system , physics , biology , radiology , quantum mechanics , microbiology and biotechnology , environmental health
It is now clear that cerebrospinal fluid [CSF, produced by the choroid plexi (CP)] plays a fundamental role in brain pathophysiology and neurodegenerative processes. However, the CP's functional activity has only been studied in vitro. This article presents a new approach for studying the CP and the CSF with 18 F‐fluorodeoxyglucose (FDG) positron emission tomography (PET). Ten elderly, non‐neurological patients underwent a 45‐min, dynamic FDG‐PET acquisition with scheduled 34 time frames. Our method provided successive images representing the FDG uptake dynamics, with calculation of three parameters of an exponential fitting function for the 34 frames and every voxel in the brain volume. Regions of interest in the CSF and CP were manually selected on the reconstructed map, and mean raw FDG uptake curves were reconstructed. We have monitored the kinetics of FDG uptake by the CP and the CSF during PET acquisition. The FDG kinetics in the CP differs markedly from those seen in the CSF and all other brain tissues. In our study population, the CP's final uptake intensity was significantly greater than that of the CSF. This work is an initial step toward using PET to evaluate CP functions in vivo. © 2011 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 21, 107–114, 2011.