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Using light to probe the brain: Intrinsic signal optical imaging
Author(s) -
Frostig Ron D.,
Masino Susan A.,
Kwon Mike C.,
Chen Cynthia H.
Publication year - 1995
Publication title -
international journal of imaging systems and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.359
H-Index - 47
eISSN - 1098-1098
pISSN - 0899-9457
DOI - 10.1002/ima.1850060212
Subject(s) - signal (programming language) , computer science , optical imaging , neuroimaging , functional imaging , functional brain imaging , computer vision , visual cortex , visualization , relevance (law) , optics , artificial intelligence , neuroscience , physics , psychology , law , political science , programming language
The theory and application of intrinsic signal optical imaging is described. This in vivo imaging method is based on capturing small activity‐related reflectance changes from the illuminated brain with sensitive cameras. Intrinsic signal imaging excels in the spatial domain (∼50 μ m) and thus enables the visualization of the small, repeated functional domains that are the basis of the functional organization of the cortex in mammals. Recent developments are described, and the advantages and limitations of this imaging method and its relevance of fMRI are discussed.