Open AccessRenal metastasis of ovarian granulosa cell tumor
Author(s) -
Togashi Kyo,
Yoneyama Tohru,
Sutoh Yoneyama Mihoko,
Yamamoto Hayato,
Hatakeyama Shingo,
Yoneyama Takahiro,
Hashimoto Yasuhiro,
Futagami Masayuki,
Ohyama Chikara
Publication year - 2022
Publication title -
iju case reports
Language(s) - English
Resource type - Journals
ISSN - 2577-171X
DOI - 10.1002/iju5.12433
Subject(s) - medicine , nephrectomy , gemcitabine , metastasis , ovarian tumor , granulosa cell , carboplatin , ovary , chemotherapy , clear cell adenocarcinoma , clear cell , renal cell carcinoma , urology , oncology , kidney , ovarian cancer , cancer , cisplatin
We would like to present a rare case of metastatic renal tumor. Case presentation A 60‐year‐old woman presented to our department with a left renal tumor. She underwent a total hysterectomy and right adnexal resection for a stage IA ovarian granulosa cell tumor approximately 15 years ago, followed by left adnexal resection and postoperative chemotherapy with gemcitabine and paclitaxel 6 years ago. She received six courses of gemcitabine and carboplatin to treat a stage IC clear cell adenocarcinoma of the ovary. The patient was diagnosed with the left renal tumor and underwent a laparoscopic left nephrectomy. Immunostaining was positive for α‐inhibin and SF‐1 and showed FOXL2 402C→G (C134W) mutation. Finally, the patient was diagnosed with renal metastasis of a granulosa cell tumor. Conclusion To our knowledge, this is a very rare case of renal metastasis of a granulosa cell tumor with the FOXL2 mutation in an adult.