Open AccessImmune‐related dermatitis during combined treatment with pembrolizumab and axitinib in a patient with metastatic renal cell\x92carcinoma with stasis dermatitis
Author(s) -
Imai Shunsuke,
Nakamura Masaki,
Chujo Satomi,
Ooki Ryousuke,
Inoue Yasushi,
Horiuchi Hajime,
Morikawa Teppei,
Uchino Keita,
Igarashi Atsuyuki,
Shiga Yoshiyuki
Publication year - 2021
Publication title -
iju case reports
Language(s) - English
Resource type - Journals
ISSN - 2577-171X
DOI - 10.1002/iju5.12356
Subject(s) - medicine , axitinib , dermatology , pembrolizumab , renal cell carcinoma , skin biopsy , immune system , biopsy , pathology , immunology , immunotherapy , sunitinib
The combination of pembrolizumab and axitinib has recently been approved as a first‐line treatment for previously untreated metastatic renal cell carcinoma. However, immune‐related adverse events are not well known. Case presentation A 65‐year‐old male was diagnosed with renal cell carcinoma with metastases to the brain and lungs. The patient had a medical history of stasis dermatitis. During the combined treatment of pembrolizumab and axitinib, blisters appeared on the lower extremities. Skin biopsy revealed septal panniculitis, pustules, and perivascular lymphocytic and neutrophilic infiltration of the skin, and the patient was diagnosed with immune‐related dermatitis. The dermatitis improved with oral prednisolone treatment. Conclusion A case of immune‐related dermatitis during combinatorial treatment with pembrolizumab and axitinib for renal cell carcinoma has been reported. Preexisting stasis dermatitis may have affected the onset and deterioration of immune‐related dermatitis.