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Muscle‐invasive bladder cancer following radiotherapy for prostate cancer is rare. We reported a case of muscle‐invasive bladder cancer who underwent robot‐assisted radical cystectomy following radiotherapy for prostate cancer.    Case presentation  A 72‐year‐old man was referred to our division with a muscle‐invasive bladder cancer. He had a history of intensity‐modulated radiation therapy for localized prostate cancer. After three courses of platinum‐based neoadjuvant chemotherapy, he obtained a radiologic complete response. He elected for robot‐assisted radical cystectomy, standard lymph node dissection, and intracorporeal ileal conduit urinary diversion. Pathological findings revealed no residual tumor within the bladder and residual tumor in the prostate. He had discharged without any complications; and quality of life had improved.    Conclusion  A robot‐assisted approach might be a potential option for well‐selected patients with muscle‐invasive bladder cancer who have previously received radiotherapy for localized prostate cancer.

Robot‐assisted radical cystectomy in a patient with muscle‐invasive bladder cancer following radiotherapy for prostate cancer