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COVID ‐19 vaccine and pregnancy outcomes: A systematic review and meta‐analysis
Author(s) -
Carbone Luigi,
Trinchillo Maria Giuseppina,
Di Girolamo Raffaella,
Raffone Antonio,
Saccone Gabriele,
Iorio Giuseppe Gabriele,
Gabrielli Olimpia,
Maruotti Giuseppe Maria
Publication year - 2022
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.14336
Subject(s) - medicine , confidence interval , odds ratio , pregnancy , gestational age , meta analysis , obstetrics , vaccination , cochrane library , observational study , medline , immunology , genetics , political science , law , biology
Objectives To explore perinatal outcomes in severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐vaccinated pregnant women compared with unvaccinated counterparts. Methods Search was conducted using Web of Science, Scopus, ClinicalTrial.gov, MEDLINE, Embase, OVID, and Cochrane Library as electronic databases. We included observational studies evaluating pregnant women undergoing SARS‐CoV‐2 vaccination and compared pregnancy and perinatal outcomes with those in unvaccinated women. Categorical variables were assessed using odds ratio (OR) with 95% confidence interval (CI), whereas for continuous variables, the results were expressed as mean difference with their 95% CI. All analyses were performed by adopting the random effect model of DerSimonian and Laird. Results There was no difference in the probability of having a small‐for‐gestational‐age fetus (OR 0.97, 95% CI 0.85–1.09; P = 0.570), but we observed a reduced probability of a non‐reassuring fetal monitoring, a reduced gestational age at delivery, and a reduced probability of premature delivery in vaccinated pregnant women versus unvaccinated ones. Conclusion The probability of small for gestational age is similar between vaccinated and unvaccinated pregnant women, and the former also had a slightly reduced rate of premature delivery.