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Seroprevalence of SARS‐CoV ‐2 antibodies among first‐trimester pregnant women during the second wave of the pandemic in India
Author(s) -
Sharma Kandala Aparna,
Singh Nilanchali,
Hillman Sara,
Mathur Purva,
Yadav Kapil,
Garg Anapti,
Dadhwal Vatsla,
Bhatla Neerja
Publication year - 2023
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.14189
Subject(s) - medicine , seroprevalence , antibody , pregnancy , titer , immunoglobulin g , immunology , area under the curve , vaccination , population , immunoglobulin m , serology , obstetrics , biology , environmental health , genetics
Objective Data on the immune response to SARS‐CoV‐2 during pregnancy are lacking and the potential role and effect of SARS‐CoV‐2 vaccination in pregnancy is yet to be completely investigated. Method This is a cross‐sectional observational study wherein pregnant women were tested for SARS‐CoV‐2 immunoglobulin M and immunoglobulin G levels, irrespective of their infective status or presence or symptomatology. Result Of the 220 pregnant women tested, 160 (72.7%) were SARS‐CoV‐2 IgG positive, 37 (16.8%) were SARS‐CoV‐2 IgM positive and 27 (16.9%) were both IgG and IgM positive. The average antibody titer found was 10.49 BAU/ml (±14.0) and 0.6 (±0.55) for anti‐SARS‐CoV‐2 IgG and IgM non neutralizing antibodies respectively. ROC analysis for SARS‐CoV‐2 IgG positivity showed a cut‐off value of 1.19 with a sensitivity of 99.3% (0.99 AUC, 95% CI) and specificity of 98.3% (0.99 AUC, 95% CI), respectively. Similarly, ROC analysis for SARS‐CoV‐2 IgM positivity showed a cut‐off value of 1 with a sensitivity of 97.3% (0.99 AUC, 95% CI) and specificity of 98.9% (0.99 AUC, 95% CI), respectively. Conclusion First trimester sero‐molecular screening suggests a high prevalence of COVID antibodies in the study population of pregnant women in the first trimester, without the patients being symptomatic.