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Cytomegalovirus seroconversion in pregnant army personnel of the Israel Defense Forces: Trends and risk factors
Author(s) -
Zemer Tov Bar,
Walfisch Asnat,
Schwartz Naama,
Meir Hila,
Kleitman Vered
Publication year - 2021
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.13679
Subject(s) - seroconversion , medicine , pregnancy , human cytomegalovirus , obstetrics , logistic regression , cytomegalovirus , odds ratio , cohort , demography , immunology , viral disease , herpesviridae , virus , genetics , sociology , biology
Objective Cytomegalovirus (CMV) seroconversion in pregnancy is a major health issue with potentially devastating fetal consequences. We opted to determine rates and trends of CMV seroconversion in pregnant army personnel and to isolate risk factors. Methods In this retrospective cohort study, all pregnancies of army personnel between 2009 and 2019 were evaluated ( n = 10 409) and all pregnancies with CMV laboratory records were included. Seroconversion rate was calculated overall and per year. Demographic and obstetrical characteristics were compared between exposed and unexposed women. Independent predictors of seroconversion were further investigated using logistic regression models. Results Cytomegalovirus serology status was available in 7665 pregnancies. Seroconversion was evident in 66 women (4.15%) among the seronegative pregnancies. Women in the seroconversion group were significantly more likely to belong to a higher social class. In the regression models, adjusted for age, place of residence, and education, higher parity (adjusted odds ratio [aOR] 2, P < 0.001) and residing in a central district (aOR 2.67, P = 0.002) were significantly associated with seroconversion. Conclusion Higher social class appears to be a significant risk factor for CMV seroconversion during pregnancy. Residing in a central district and higher parity appear to be independently associated with an increased risk for seroconversion during pregnancy among army personnel.