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Maternal and perinatal outcomes of a venous thromboembolism high‐risk cohort using a multidisciplinary treatment approach
Author(s) -
Ernst Daniel M.,
Oporto Joaquín I.,
Zuñiga Pamela A.,
Pereira Jaime I.,
Vera Claudio M.,
Carvajal Jorge A.
Publication year - 2021
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.13628
Subject(s) - medicine , thrombophilia , obstetrics , pregnancy , venous thromboembolism , cohort study , prospective cohort study , antiphospholipid syndrome , cohort , thrombosis , pediatrics , surgery , genetics , biology
Objective To evaluate the maternal and perinatal outcomes in a cohort of pregnant women at high risk of venous thromboembolism (VTE). Methods Women at high risk of VTE were evaluated in a multidisciplinary program using a complete diagnostic workup, and specific prophylactic or therapeutic treatment. Results Women were considered at high risk of VTE in 57% (85/148) because of prior (75) or current (10) thromboembolism, and in 27% (40/148) of the cases due to adverse obstetric history. Thrombophilia was diagnosed in 57% of the cases (85/148), either in patients with previous thromboembolism (48%, 41/85) or without a history of thrombosis (70%, 44/63). The most common thrombophilia was antiphospholipid syndrome in 34% (29/85) of the cases. Under respective prophylactic or therapeutic treatment, there were no VTE during pregnancy (0%, 0/148), whereas four events occurred during the puerperium (3%, 4/148). An adverse obstetric outcome was present in 5% (7/148) of all pregnancies, with four early spontaneous abortions (3%, 4/148) and three late miscarriages (2%, 3/148). Conclusion Pregnant women at high risk of VTE can be effectively managed using a risk‐adapted treatment. Our results support prospective enrollment and a multidisciplinary assessment of VTE in high‐risk pregnant women.