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The impact of lymph node dissection on apparent Stage I epithelial ovarian carcinoma: A population‐based study
Author(s) -
Chen Qian,
Wang Shu,
Lang JingHe
Publication year - 2021
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.13627
Subject(s) - lymphadenectomy , medicine , lymph node , dissection (medical) , stage (stratigraphy) , oncology , serous fluid , ovarian cancer , cohort , lymph , proportional hazards model , propensity score matching , metastasis , gynecology , cancer , surgery , pathology , biology , paleontology
Objective To explore the impact of lymphadenectomy on the prognosis of women of reproductive age with clinically apparent Stage I epithelial ovarian cancer (EOC). Methods Data of women of reproductive age with Stage I EOC, diagnosed between 2010 and 2016, were extracted from the Surveillance, Epidemiology, and End Results database. Five‐year cancer‐specific survival (CSS) was evaluated using the Kaplan–Meier method. Multivariate Cox analysis was performed to evaluate the effect of lymph node dissection on survival. Propensity score (PS) matching was conducted to balance various clinicopathologic factors. Results Of 2222 patients included, 1609 (72.4%) received lymph node dissection. The rate of histopathologically confirmed lymph node metastasis was highest in serous subtype (10.2%) and lowest in mucinous subtype (2.2%). No significant difference between the lymphadenectomy and non‐lymphadenectomy groups in 5‐year CSS was observed in the original cohort ( P = 0.364) or in the PS matching cohort ( P = 0.248). Nevertheless, there was a significant difference between the lymphadenectomy and non‐lymphadenectomy groups for patients with Stage IC EOC (92.4% vs. 88.1%, P = 0.027). According to the multivariate analysis, performance of the lymphadenectomy was not significantly associated with CSS in the original cohort ( P = 0.163) or the PS matching cohort ( P = 0.101). Conclusion Dissection of lymph nodes was not significantly associated with improved prognosis for most Stage I EOC, but, lymphadenectomy may be necessary for women of reproductive age with Stage IC subtype.