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The effectiveness of using a molded sorbent: Modified polyvinylpyrrolidone for the combined treatment of chronic endometritis
Author(s) -
Barinov Sergey V.,
Tirskaya Yuliya I.,
Borisova Anna V.,
Pyanova Lidiya G.,
Di Renzo Gian Carlo
Publication year - 2021
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.13609
Subject(s) - medicine , antibiotics , gastroenterology , endometritis , uterine cavity , antagonist , polyvinylpyrrolidone , urology , surgery , receptor , uterus , microbiology and biotechnology , pregnancy , genetics , biology , chemical engineering , engineering
Objective To improve the management of patients with chronic endometritis (CE) by using a molded sorbent—modified by polyvinylpyrrolidone (FSMP). Methods This prospective study included 70 patients with CE divided into two groups: group 1 ( n = 23) received traditional antibiotic therapy (from days 3 to 10 of the menstrual cycle); group 2 ( n = 47), received antibiotics and FSMP was inserted from days 5 to 10. Results At the end of therapy, group 1 had massive growth of pathogenic microflora in 21.7%, moderate growth in 69.6%, and no growth in 8.7% of cases. In group 2, after combined therapy, massive growth was observed in 4.3%, moderate growth in 44.7%, and no growth in 51.0%. In group 2 after 5 days, serum levels of interleukin‐1β (IL‐1β) were 1.9 times, of IL‐6 were 7.0 times, and of IL‐8 and IL‐1 receptor antagonist were 1.3 times lower than in group 1. In uterine cavity aspirates, IL‐1β decreased around 4.8 times, IL‐6 by 11.8 times, IL‐8 by 3.2 times, tumor necrosis factor‐α by 3.9 times, and IL‐1 receptor antagonist by 2.1 times in comparison to group 1. Conclusion Combined therapy of FSMP with antibiotics is more effective in treating CE, because it contributes to the almost complete elimination of pathogens and toxins from the uterine cavity, blocking the local pro‐inflammatory cascade.