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Maternal vitamin D, oxidative stress, and pre‐eclampsia
Author(s) -
Wei Shu Qin,
Bilodeau JeanFrançois,
Julien Pierre,
Luo ZhongCheng,
Abenhaim Haim A.,
Bi Wei Guang,
Nuyt Anne Monique,
Leduc Line,
Audibert François,
Fraser William D.
Publication year - 2021
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.13559
Subject(s) - medicine , vitamin d and neurology , oxidative stress , eclampsia , odds ratio , pregnancy , vitamin d deficiency , prospective cohort study , confidence interval , endocrinology , gestation , population , preeclampsia , biology , genetics , environmental health
Objective To examine the associations between risk of pre‐eclampsia and pregnancy levels of maternal 25‐hydroxyvitamin D (25[OH]D) and oxidative stress biomarkers. Methods A nested case–control study (n = 99; 34 cases; 65 controls) within a prospective pregnancy cohort. Maternal 25(OH)D and oxidative stress markers (six isomers of F 2 ‐isoprostanes; F 2 ‐isoPs) were measured in plasma at 12–18 and 24–26 gestational weeks. Vitamin D deficiency was defined as 25[OH]D less than 50 nmol/L. Results Maternal vitamin D deficiency was associated with increased 8‐iso‐PGF 2α ( P = 0.037), 15( R )‐PGF 2α ( P = 0.004), (±)5‐iPF 2α ‐VI ( P = 0.026) at 12–18 weeks. Vitamin D deficiency was inversely associated with 8‐iso‐PGF 2α ( P = 0.019) and (±)5‐iPF 2α ‐VI isomer ( P = 0.010) at 24–26 weeks. Both maternal vitamin D deficiency (adjusted odds ratio [aOR], 4.79; 95% confidence interval [CI], 1.67–13.75) and increased (±)5‐iPF 2α ‐VI (aOR, 2.46; 95% CI, 1.16–5.22) at 24–26 weeks were associated with risk of pre‐eclampsia. However, the interaction test between 25(OH)D and (±)5‐iPF 2α ‐VI was not significant ( P = 0.143). Conclusion Plasma 25(OH)D below 50 nmol/L was associated with increased oxidative stress levels during pregnancy as measured by two F 2 ‐isoP isomers, including the well‐studied marker 8‐iso‐PGF 2α . Whether vitamin D‐induced oxidative stress mediates the risk of pre‐eclampsia warrants future study.