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Cervical cancer in women under 25 years of age and outside the screening age: Diagnosis profile and long‐term outcomes
Author(s) -
Teixeira Julio Cesar,
Santos Daniel Zaidan,
Campos Cirbia Silva,
Vale Diama Bhadra,
Bragança Joana Froes,
Zeferino Luiz Carlos
Publication year - 2021
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.13553
Subject(s) - medicine , asymptomatic , stage (stratigraphy) , cervical cancer , histology , cytology , cancer , adenosquamous carcinoma , gynecology , adenocarcinoma , pathology , paleontology , biology
Objective To evaluate the pattern of cervical cancer (CC) diagnosis and outcomes in women under 25. Methods Thirty‐two women younger than 25 years of age treated between 2001 and 2016 were studied and the year, symptom or cytology before diagnosis, time since sexual debut, age group, histology, and stage were considered. Data were compared with older age groups, and survival analysis was performed using a subset of them. Results Thirty‐two CC diagnoses (1.5% of all cases) exhibited a positive linear trend ( P = 0.075). Driven by cytology, 18 were asymptomatic and 14 were symptomatic (with vaginal bleeding in 11). The mean time since sexual debut was 6.9 years. Advanced stage (44% vs 29%) and adenosquamous histology (12.5% vs 1.7%–5.0%) were higher in younger women. Five‐year overall survival rate was 76%, better for squamous cell carcinoma (SCC) (86% vs 43% for other histologies; P = 0.018). There were seven deaths, all within 15 months of diagnosis. Age groups of less than 25 years (53%) and 25–29 years (48.5%) had similar proportions of Stage IA1. Conclusion The rate of CC‐diagnosed women under 25 years was 1.5% of all cases, exhibiting more advanced stage and non‐SCC histology. For asymptomatic women, cytology allowed the diagnosis at an early stage. Being symptomatic and non‐SCC was associated with a higher proportion of advanced stages and poor survival.