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Age‐related diagnostic threshold of anti‐Müllerian hormone for polycystic ovarian syndrome
Author(s) -
Kakkad Vivek,
Reddy Nellepalli Sanjeeva,
Nihlani Harsh,
Gundewar Tejas
Publication year - 2021
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.13515
Subject(s) - medicine , anti müllerian hormone , gynecology , polycystic ovary , retrospective cohort study , population , obstetrics , hormone , insulin , insulin resistance , environmental health
OBJECTIVE To ascertain the threshold value for anti‐Müllerian hormone (AMH) in the diagnosis of polycystic ovarian syndrome (PCOS) in an Indian population. METHODS A retrospective observational study was carried out on infertile women at the Department of Reproductive Medicine and Surgery at a tertiary hospital from January 2017 to November 2019. Serum AMH was analyzed with Access AMH chemiluminescent immunoassay. Receiver operating characteristic curves were used to calculate the diagnostic threshold value of serum AMH in two age groups: 20–29 and 30–39 years. RESULTS Of 688 women, 200 (29.1%) were diagnosed with PCOS by the Rotterdam criteria: 98/282 (34.8%) aged 20–29 years and 102/406 (25.4%) aged 30–39 years. Mean serum AMH was 5.07 ± 3.97 and 4.330 ± 7.15 ng/ml in women aged 20–29 and 30–39 years, respectively. A threshold value of serum AMH above 3.75 ng/ml was predictive of PCOS by Youden's J statistics in the entire cohort, whereas it was 5.46 and 3.46 ng/ml in women aged 20–29 and 30–39 years, respectively. CONCLUSION Serum AMH of 5.46 and 3.46 ng/ml in women aged 20–29 and 30–39 years, respectively, can be used to diagnose PCOS when there is a diagnostic dilemma in the Rotterdam criteria.