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The optimal cut‐off value of immunohistochemical parameter P53 for predicting recurrence of endometrial cancer
Author(s) -
Jia Mingzhu,
Jiang Peng,
Hu Jing,
Huang Zhen,
Deng Ying,
Hu Zhuoying
Publication year - 2021
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.13498
Subject(s) - medicine , endometrial cancer , proportional hazards model , receiver operating characteristic , youden's j statistic , immunohistochemistry , stage (stratigraphy) , oncology , radiation therapy , cancer , chemotherapy , adjuvant , gastroenterology , paleontology , biology
Objective To explore the optimal cut‐off value of immunohistochemical parameter P53 for predicting the recurrence of Stage I–III endometrial cancer. Methods A total of 473 patients who were treated between October 2013 and May 2018 were retrospectively studied. Receiver operating characteristic (ROC) curves and the Youden index were used to calculate the optimal cut‐off value of P53. Cox regression analysis was used to detect the association between the threshold of P53 and recurrence of endometrial cancer. Recurrence‐free survival (RFS) and overall survival (OS) were exhibited by Kaplan–Meier curve. Results The study showed that 67% was the optimal cut‐off value of P53 to predict the recurrence of endometrial cancer. P53 above 67% was an independent predictor for relapse of endometrial cancer ( p < 0.001). The 3‐year RFS was 89.7% in the low‐value group and 66.6% in the high‐value group ( p < 0.001), while the 3‐year OS was 93.9% and 76.4%, respectively ( p < 0.001). Furthermore, the 3‐year RFS of patients who did not receive adjuvant chemotherapy or radiotherapy was 95.7% and 78.2% between the two groups ( p < 0.001). Conclusion The optimal cut‐off value of immunohistochemical parameter P53 for predicting recurrence was confirmed as 67% and a P53 index above 67% was an independent prognostic factor.