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The estradiol/oocyte ratio predicts the MII oocyte rate, but not live‐birth rate in a depot gonadotropin‐releasing hormone agonist long protocol
Author(s) -
Ai Jihui,
Jin Lei,
Zheng Yu,
Gong Jingji,
Chen Biao,
Dong Xiyuan
Publication year - 2021
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.13417
Subject(s) - oocyte , miscarriage , live birth , in vitro fertilisation , pregnancy , pregnancy rate , medicine , andrology , gonadotropin , human fertilization , endocrinology , biology , hormone , gynecology , embryo , genetics , anatomy
Objective To investigate whether the estradiol/oocyte ratio (E 2 /O) can predict ovarian response and pregnancy outcomes. Methods This is a retrospective cohort study on 1838 individuals undergoing in vitro fertilization with a depot gonadotropin‐releasing hormone agonist (GnRH‐a) long protocol. The patients were grouped by the quartiles of E 2 /O: <131.2, 131.2–178.0, 178.0–242.9, and >242.9 pg/mL. ANOVA and χ 2 test with the Bonferroni adjustment were used for statistical analysis. Results With the rise of E 2 /O, the MII oocyte rate increased, whereas the number of oocytes retrieved decreased. The number of MII oocytes, fertilization rate, and the number of high‐grade embryos were similar among the four groups. There were no differences in live‐birth rate, clinical pregnancy rate, ectopic pregnancy rate, and miscarriage rate, but there was a trend towards a higher miscarriage rate in the patients with E 2 /O between 131.2 and 242.9 pg/mL. Conclusion E 2 /O indicates the percentage of MII oocytes, but not the quality of an individual follicle. E 2 /O does not predict live birth in a depot GnRH‐a long protocol; however, there is a trend towards a higher risk for miscarriage in the patients with E 2 /O between 131.2 and 242.9 pg/mL.