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Comparison of uterine artery Doppler measurements at 6 weeks of pregnancy after IVF between pregnancies that resulted in miscarriage and ongoing pregnancies
Author(s) -
Guo Jun,
Chaemsaithong Piya,
Huang Jin,
Chung Jacqueline P.W.,
Huang Junhong,
Poon Liona C.Y.,
Li Tin Chiu
Publication year - 2021
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.13371
Subject(s) - medicine , miscarriage , obstetrics , pregnancy , uterine artery , gynecology , embryo transfer , in vitro fertilisation , prospective cohort study , gestation , surgery , genetics , biology
Objective To compare uterine artery pulsatility index (UTPI) at 6 weeks of pregnancy following in vitro fertilization (IVF) and embryo transfer (ET) between clinical pregnancies that resulted in a miscarriage and those that were ongoing beyond 12 weeks. Methods A prospective observational study was conducted in an IVF unit at Prince of Wales Hospital, Hong Kong, between December 1, 2017 and December 31, 2019. UTPI was measured at 6 weeks of pregnancy among women who conceived following IVF/ET. Results Among 153 participants, 22 (14.4%) had a miscarriage whereas 131 (85.6%) had an ongoing pregnancy beyond 12 weeks. Median UTPI in pregnancies that ended in a miscarriage was significantly lower than those that progressed beyond 12 weeks (2.1, IQR 1.9–2.4 vs 2.50, IQR 2.2–2.9, respectively; P <0.001). The likelihood of the pregnancy ending in a miscarriage when the UTPI was above the 75th percentile (>2.9), between the 25th–75th percentiles (2.2–2.9), and below the 25th percentile (<2.2) was 0%, 13.2%, and 27.7%, respectively ( P =0.001). Conclusions IVF pregnancies that resulted in a miscarriage were associated with reduced resistance to uterine artery blood flow at 6 weeks of pregnancy.

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