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Predictors of live birth rate in women with diminished ovarian reserve
Author(s) -
Huang Rui,
Wang NingNing,
Li TingTing,
Li ManChao,
Yang Xing,
Liang XiaoYan
Publication year - 2020
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.13174
Subject(s) - live birth , medicine , in vitro fertilisation , logistic regression , ovarian reserve , obstetrics , embryo transfer , demography , gynecology , pregnancy , infertility , biology , genetics , sociology
Objective To investigate the chance of live birth after several oocyte retrieval cycles in patients with diminished ovarian reserve ( DOR ) and identify the possible predictors. Methods A retrospective analysis of 931 patients with DOR who underwent in vitro fertilization at a university hospital in China between January 2012 and December 2014. All data for fresh and the associated frozen‐thawed embryo transfer attempts were analyzed. Conditional and cumulative live birth rates ( LBR s) were calculated. Mediation and logistic regression analyses were performed to determine the predictors of live birth. Results Conditional LBR s remained around 10.0% in the first five cycles. Conservative cumulative LBR s ( CLBR s) reached 22.0% after three cycles and increased to 24.8% after six cycles; optimal CLBR s increased from 12.9% to nearly 50.0% after six cycles. Patient age and the number of good‐quality embryos were two key predictors in determining the conditional and conservative LBR s. Conclusion For patients with DOR , conditional LBR remained constant in the first five cycles, and patients should be encouraged to continue to three or five completed cycles to maximize their chance of live birth. Patient age and the number of good‐quality embryos were two key factors to predict live birth.