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Delivery in pregnant women infected with SARS ‐CoV‐2: A fast review
Author(s) -
Parazzini Fabio,
Bortolus Renata,
Mauri Paola Agnese,
Favilli Alessandro,
Gerli Sandro,
Ferrazzi Enrico
Publication year - 2020
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.13166
Subject(s) - medicine , vaginal delivery , pregnancy , gestational age , obstetrics , transmission (telecommunications) , covid-19 , pediatrics , disease , infectious disease (medical specialty) , genetics , electrical engineering , biology , engineering
Background Few case reports and clinical series exist on pregnant women infected with SARS ‐CoV‐2 who delivered. Objective To review the available information on mode of delivery, vertical/peripartum transmission, and neonatal outcome in pregnant women infected with SARS ‐CoV‐2. Search strategy Combination of the following key words: COVID ‐19, SARS ‐CoV‐2, and pregnancy in Embase and PubMed databases. Selection criteria Papers reporting cases of women infected with SARS ‐CoV‐2 who delivered. Data collection and analysis The following was extracted: author; country; number of women; study design; gestational age at delivery; selected clinical maternal data; mode of delivery; selected neonatal outcomes. Main results In the 13 studies included, vaginal delivery was reported in 6 cases (9.4%; 95% CI , 3.5–19.3). Indication for cesarean delivery was worsening of maternal conditions in 31 cases (48.4%; 95% CI , 35.8–61.3). Two newborns testing positive for SARS ‐CoV‐2 by real‐time RT ‐ PCR assay were reported. In three neonates, SARS ‐CoV‐2 IgG and IgM levels were elevated but the RT ‐ PCR test was negative. Conclusions The rate of vertical or peripartum transmission of SARS ‐CoV‐2 is low, if any, for cesarean delivery; no data are available for vaginal delivery. Low frequency of spontaneous preterm birth and general favorable immediate neonatal outcome are reassuring.