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Effect of current guidelines on prevention of pre‐eclampsia with low‐dose aspirin in primary settings: A population‐based case–control study
Author(s) -
PremruSrsen Tanja,
Kocic Zorana,
Verdenik Ivan
Publication year - 2020
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.13133
Subject(s) - medicine , eclampsia , odds ratio , propensity score matching , aspirin , confidence interval , obstetrics , population , pregnancy , small for gestational age , number needed to harm , preeclampsia , gestational age , pediatrics , number needed to treat , relative risk , environmental health , genetics , biology
Objective To evaluate the effect of low‐dose aspirin, which was administered at or before the 16th week of pregnancy due to maternal characteristics and history of a pre‐existing medical condition, on prevention of pre‐eclampsia, and on the birth of a small‐for‐gestational‐age ( SGA ) neonate without pre‐eclampsia in nulliparas in primary settings. Methods We performed a case–control study using population‐based data on 47 271 nulliparas with a singleton pregnancy who delivered in Slovenia from 2013 to 2017. The treated group received low‐dose aspirin. For the untreated group, propensity score matching was used to perform a 1:1 matching. In the matched sample, we calculated the odds ratios ( OR ) with a 95% confidence interval (95% CI ) with a two‐way test for pre‐eclampsia, as well as SGA neonates. Results In the treated group (n=584), the odds for an SGA neonate were significantly increased by 42.7% ( OR 1.427, 95% CI 1.001–2.034). However, we found no significant effect on the odds for pre‐eclampsia ( OR 1.308, 95% CI 0.847–2.022). Conclusions In anticipation of more substantial population‐based data studies, in the Slovenian population, preventive treatment with low‐dose aspirin due to maternal characteristics and history of a pre‐existing medical condition is not beneficial for the prevention of pre‐eclampsia and can harm fetal growth.

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