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Anti‐Müllerian hormone as a marker of abortion in the first trimester of spontaneous pregnancy
Author(s) -
Kostrzewa Marta,
Żyła Monika,
Garnysz Karolina,
Kaczmarek Beata,
Szyłło Krzysztof,
Grzesiak Mariusz
Publication year - 2020
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.13104
Subject(s) - medicine , anti müllerian hormone , abortion , pregnancy , gynecology , obstetrics , confidence interval , prospective cohort study , hormone , endocrinology , biology , genetics
Objective To assess anti‐Müllerian hormone ( AMH ) levels as a marker of early abortion in the first trimester among women younger than 35 years. Methods Prospective study of women aged 18–34 years with a spontaneous pregnancy at less than 12.6 gestational weeks in Łódź, Poland, between January 2017 and November 2018. Cases of anembryonic abortion and assisted conception were excluded. Blood samples were collected and assayed for serum AMH levels. Data were compared between women with an embryo with no cardiac activity by ultrasound (n=30) and those with a normal embryo (n=33) by using Statistica12 software. Results The 10th and 90th percentiles of serum AMH concentration among control women were used to identify a reference AMH range (1.1–4.5 ng/ mL ). Risk of pregnancy loss in the first trimester was found to be higher for both low AMH (<1.1 ng/ mL ; relative risk [ RR ], 3.66; 95% confidence interval [ CI ], 2.1–6.4; P <0.001) and high AMH (>4.5 ng/ mL ; RR , 3.0; 95% CI , 1.61–5.59; P <0.001). Conclusions Both very low and very high AMH concentrations were found to significantly increase the risk of abortion in the first trimester of pregnancy. Serum AMH might be a valuable marker to predict the risk of early abortion.