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Neurological complications associated with emerging viruses in Brazil
Author(s) -
Angelo Jussara R.,
Fuller Trevon L.,
Leandro Bianca B.S.,
Praça Heitor L.F.,
Marques Renata D.,
Ferreira João M.C.,
Pupe Camila C.B.,
Perez Olívia C.,
NielsenSaines Karin,
Nascimento Osvaldo J.M.,
Sabroza Paulo C.
Publication year - 2020
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.13050
Subject(s) - medicine , guillain barre syndrome , incidence (geometry) , zika virus , dengue virus , dengue fever , pediatrics , chronic inflammatory demyelinating polyneuropathy , virus , immunology , antibody , physics , optics
Objective To test the hypotheses that emerging viruses are associated with neurological hospitalizations and that statistical models can be used to predict neurological sequelae from viral infections. Methods An ecological study was carried out to observe time trends in the number of hospitalizations with inflammatory polyneuropathy and Guillain‐Barré syndrome ( GBS ) in the state of Rio de Janeiro from 1997 to 2017. Increases in GBS from month to month were assessed using a Farrington test. In addition, a cross‐sectional study was conducted analyzing 50 adults hospitalized for inflammatory polyneuropathies from 2015 to 2017. The extent to which Zika virus symptoms explained GBS hospitalizations was evaluated using a calibration test. Results There were significant increases (Farrington test, P <0.001) in the incidence of GBS following the introduction of influenza A/H1N1 in 2009, dengue virus type 4 in 2013, and Zika virus in 2015. Of 50 patients hospitalized, 14 (28.0%) were diagnosed with arboviruses, 9 (18.0%) with other viruses, and the remainder with other causes of such neuropathies. Statistical models based on cases of emerging viruses accurately predicted neurological sequelae, such as GBS . Conclusion The introduction of novel viruses increases the incidence of inflammatory neuropathies.