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Cervical intraepithelial neoplasia in women who had vaccination against HPV
Author(s) -
Bogani Giorgio,
Serati Maurizio,
Leone Roberti Maggiore Umberto,
Ditto Antonino,
Gardella Barbara,
Ferrero Simone,
Spinillo Arsenio,
Ghezzi Fabio,
Raspagliesi Francesco
Publication year - 2019
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12934
Subject(s) - medicine , vaccination , cervical intraepithelial neoplasia , dysplasia , human papillomavirus , gynecology , retrospective cohort study , hpv infection , young adult , obstetrics , cervical cancer , immunology , cancer
Objective To investigate the characteristics of women developing cervical intraepithelial neoplasia who had had a vaccination against human papillomavirus ( HPV ). Methods A retrospective cohort study was carried out of women diagnosed with moderate or severe cervical dysplasia ( CIN 2+) in four Italian centers between 2015 and 2017. All women included had had previous bivalent or quadrivalent vaccination against HPV . Results The present study included 43 patients affected by CIN 2+. The median age was 28 (range, 21–41) years. Ten (23.3%) patients did not have a diagnosis of specific HPV type(s) involved: high‐risk HPV was detected in 7 (16.3%) women while HPV testing was negative in 3 (6.9%) women. Lesions related to HPV 16 were found in two patients. HPV types covered by nonavalent vaccination were diagnosed in 27/33 (81.8%) women. HPV types not covered by nonavalent vaccination were diagnosed in 6 (18.2%) women. Co‐infections are most commonly detected in women with HPV s other than those included in the nonavalent vaccination ( P =0.024). Conclusion Cervical dysplasia occurring after HPV vaccination is a rare condition. Theoretically, nonavalent vaccination should improve protection against more than 80% of HPV ‐related lesions compared to other vaccines.