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Prognostic factors for pregnancy after intrauterine insemination
Author(s) -
Ejzenberg Dani,
Gomes Tiago J.O.,
Monteleone Pedro A.A.,
Serafini Paulo C.,
SoaresJr José M.,
Baracat Edmund C.
Publication year - 2019
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12898
Subject(s) - medicine , intrauterine insemination , pregnancy , receiver operating characteristic , gynecology , logistic regression , infertility , follicle , human chorionic gonadotropin , obstetrics , artificial insemination , hormone , biology , genetics
Objective To evaluate prognostic factors for pregnancy after intrauterine insemination ( IUI ). Methods A retrospective study was conducted among couples who underwent IUI at Universidade de São Paulo, Brazil, between January 31, 2008, and April 30, 2016. The main outcome was a positive β human chorionic gonadotropin (β‐ hCG ) test result after IUI . Univariate analyses were used to determine predictors of pregnancy. Selected numerical variables were categorized to maximize the area under the receiver operating characteristic ( ROC ) curve. Logistic regression was performed using the backward method. The quality of the model was evaluated using the R 2 (Nagelkerke) and Hosmer‐Lemeshow tests. Results Of 355 insemination cycles, 56 (15.8%) resulted in a positive β‐ hCG test result. The predictors and cutoff values that maximized the area under the ROC curve were as follows: follicle‐stimulating hormone (<7.7 mIU / mL ; P <0.001); duration of infertility (<62 menses; P <0.001); number of follicles greater than or equal to 14 mm (>1 follicle; P <0.001); baseline spermatozoa concentration (>52.0 million/ mL ; P =0.007); total ejaculate (>123.7 million; P =0.003); and grade B motility (>35%; P =0.013). These factors were able to predict 50.4% of the positive test results ( R 2 ). Conclusion Prognostic factors for pregnancy identified approximately half of all successful outcomes after IUI .