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Short‐term efficacy, safety, and cost‐effectiveness of transarterial chemoembolization with drug‐eluting beads versus synchronous radiochemotherapy for cervical cancer
Author(s) -
Song Jingjing,
Chen Weiqian,
Zhu Xiaohua,
Zhao Zhongwei,
Chen Minjiang,
Huang Lingcong,
Tu Jianfei,
Zhou Hongyou,
Zhou Lihong,
Ji Jiansong
Publication year - 2019
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12888
Subject(s) - medicine , retrospective cohort study , cervical cancer , proportional hazards model , oncology , adverse effect , univariate analysis , logistic regression , cancer , surgery , multivariate analysis
Objective To investigate the short‐term efficacy and safety of transarterial chemoembolization with drug‐eluting beads ( DEB ‐ TACE ) versus synchronous radiochemotherapy among women with cervical cancer. Methods A retrospective cohort study of women treated by synchronous radiochemotherapy (n=20) and DEB ‐ TACE (n=20) at a single center in China between November 2015 and September 2017. Inclusion criteria were pathologic diagnosis of cervical cancer, age at least 18 years, and complete clinicopathologic information. Hospital stay, direct medical cost, resection frequency, adverse events, treatment responses, progression‐free survival ( PFS ) and overall survival ( OS ) were compared between treatments. Results There was no difference in treatment responses, PFS , or OS between the two groups. Hospital stay was shorter, direct medical costs were lower, and resection rate was higher in the DEB ‐ TACE group than in the radiochemotherapy group (all P <0.05). In univariate and multivariate logistic regression analysis, no factor was associated with complete response. No predictive factor for PFS or OS was identified by Cox proportional regression analysis. Fewer adverse advents were recorded in the DEB ‐ TACE group than in the synchronous radiochemotherapy group. Conclusion Among women with cervical cancer, DEB ‐ TACE achieved equal short‐term efficacy, better tolerance, less hospital stay and medical costs, and higher resection rates as compared with synchronous radiochemotherapy.