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The effect of concurrent endometriosis on the prognosis of women with ovarian clear cell or endometrioid carcinoma
Author(s) -
Ju U Chul,
Kang Woo Dae,
Kim Seok Mo
Publication year - 2019
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12861
Subject(s) - medicine , endometriosis , clear cell carcinoma , hazard ratio , stage (stratigraphy) , ovarian cancer , oncology , ovarian carcinoma , carcinoma , gynecology , univariate analysis , retrospective cohort study , clear cell , confidence interval , multivariate analysis , cancer , paleontology , biology
Objectives To evaluate features of ovarian clear cell carcinoma ( CCC ) and endometrioid carcinoma ( EC ) by presence of endometriosis among women with endometriosis‐associated ovarian cancer ( EAOC ). Methods A retrospective review of the medical records of 578 women diagnosed and treated for ovarian cancer at a university hospital in Korea between July 2004 and December 2016. Clinical and prognostic features of ovarian CCC and EC were compared between women with endometriosis and those without. Results Ovarian CCC and EC were diagnosed at an earlier FIGO stage for women with endometriosis than for those without ( P =0.033). The 5‐year disease‐free survival ( DFS ) and overall survival ( OS ) were 77.6% vs 65.0% ( P =0.038) and 80.3% vs 70.9% ( P =0.048), respectively. In univariate analysis, advanced stage, higher grade, bilateral tumors, lymph node metastasis, residual tumor greater than 1 cm, and non‐concurrent endometriosis were related to shorter DFS and OS ; however, residual tumor greater than 1 cm was the only independent predictor in multivariate analysis ( DFS : hazard ratio ( HR ), 9.83; 95% confidence interval ( CI ), 4.84–19.93; OS : HR , 5.07; 95% CI , 2.33–11.03). No factors affected survival after stratification by stage. Conclusion No association was found between the presence of endometriosis and the prognosis of ovarian CCC or EC .