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A community‐based, cross‐sectional study of hr HPV DNA self‐sampling‐based cervical cancer screening in rural Karnataka, India
Author(s) -
Adsul Prajakta,
Srinivas Vijaya,
Gowda Savitha,
Nayaka Shivamma,
Pramathesh Rashmi,
Chandrappa Kavitha,
Khan Anisa,
Jayakrishna Poornima,
Madhivanan Purnima
Publication year - 2019
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12859
Subject(s) - medicine , cervical cancer , cross sectional study , caste , asymptomatic , cancer , cancer screening , sampling (signal processing) , family medicine , rural area , obstetrics , environmental health , gynecology , demography , pathology , linguistics , philosophy , filter (signal processing) , computer science , computer vision , sociology
Objective To examine the feasibility of implementing a high‐risk HPV (hr HPV ) DNA ‐based screening program for cervical cancer and the prevalence of hr HPV DNA ‐positive women in a community setting in rural India. Methods A cross‐sectional study was conducted at the community level in the Hunsur taluk of the Mysore district from January to August 2016. Cervical cancer screening was conducted with self‐collected vaginal samples that were analyzed using the Hybrid Capture 2 ( HC 2) assay (Qiagen, USA ). Results The majority of participants were aged 30–39 years, with no formal schooling, from a lower caste, and lived below an annual household income of US $1499. After group health education and one‐on‐one counseling, a total of 473 women underwent self‐sampling. Of these, 36 (7.6%) were positive for hr HPV and only 24 (66.6%) underwent follow‐up diagnostic triaging. Cancer was detected in two women, who were referred to appropriate healthcare facilities for further treatment. Conclusion Implementation of hr HPV DNA ‐based screening tests using self‐sampling can be feasible in rural settings in India. However, substantial resources are required for providing health education and one‐on‐one counseling to inform asymptomatic women about the benefits of testing and, more importantly, to improve compliance with follow‐up.