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Association of ERAP 2 gene variants with risk of pre‐eclampsia among Iranian women
Author(s) -
Soltani Sareh,
Nasiri Mahboobeh
Publication year - 2019
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12816
Subject(s) - medicine , genotyping , eclampsia , genotype , allele , haplotype , allele frequency , polymorphism (computer science) , obstetrics , pregnancy , preeclampsia , case control study , gynecology , genetics , gene , biology
Objectives To determine the association between ERAP 2 rs2549782 and rs17408150 polymorphisms and pre‐eclampsia among Iranian women. Methods A retrospective case–control study comparing 319 women with pre‐eclampsia and 291 normotensive pregnant Iranian women between January and August 2016. Pre‐eclampsia was diagnosed by the International Society for the Study of Hypertension in Pregnancy's criteria. Demographic data were collected by oral interview. Genotyping was done by allele‐specific PCR . Data were analyzed using SPSS v. 16. Results The frequency of the rs2549782 TT genotype was 31.0% and 27.5% among cases and controls, respectively ( P =0.006). There was no difference in the frequency of the T allele between groups ( P >0.05). Regarding the rs17408150 polymorphism, a high portion of women with pre‐eclampsia was homozygous for the AA genotype ( P <0.001). The frequency of the A allele was 32.5% and 25.05% among cases and controls, respectively ( P =0.004). The combined haplotype of the rs2549782A and rs17408150G alleles was associated with increased risk of pre‐eclampsia ( P =0.031). Conclusion ERAP 2 gene polymorphisms were associated with the risk of pre‐eclampsia in an Iranian population. The results provide further evidence of the role of ERAP 2 in the pathophysiology of this disease.