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Relationships of serum placental growth factor and soluble fms‐like tyrosine kinase‐1 with fetal and uterine artery Doppler indices in pre‐eclampsia
Author(s) -
Li Jingyu,
Cai Ailu,
Yuan Qian,
Ding Hao,
Zhao Dan
Publication year - 2019
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12796
Subject(s) - medicine , eclampsia , umbilical artery , uterine artery , fetus , gestational age , endocrinology , placenta , obstetrics , gynecology , gestation , pregnancy , biology , genetics
Objective To compare serum placental growth factor (Pl GF ) and soluble fms‐like tyrosine kinase‐1 ( sF lt‐1) concentrations among women with pre‐eclampsia and healthy control women and to evaluate the associations of serum Pl GF and sF lt‐1 with fetal and uterine artery Doppler indices in pre‐eclampsia. Methods A prospective cross‐sectional study of 33 women with pre‐eclampsia and 33 normotensive pregnant women attending a university hospital in China between January and November 2014. Serum Pl GF and sF lt‐1 were assayed by enzyme linked immunosorbent assays. Doppler indices of the uterine artery, umbilical artery, fetal middle cerebral artery, and ductus venosus were measured. Results The pulsatility index of the uterine artery was negatively correlated with Pl GF ( r , −0.487; P =0.004) and positively correlated with sF lt‐1 ( r , 0.420; P =0.015). Gestational age at birth was positively correlated with Pl GF ( r , 0.601, P <0.001) and negatively correlated with sF lt‐1 ( r , −0.568; P =0.001). Birth weight was positively correlated with Pl GF ( r , 0.555; P =0.001) and negatively correlated with sF lt‐1 ( r , −0.552; P =0.001). Apgar score was negatively correlated with sF lt‐1 ( r , −0.427; P =0.017). Conclusion Lower Pl GF and higher sF lt‐1 levels in maternal serum were significantly associated with increased uterine arterial impedance in pre‐eclampsia.