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Meta‐analysis of the association between maternal subclinical hypothyroidism and gestational diabetes mellitus
Author(s) -
Jia Minghan,
Wu Yanxin,
Lin Bo,
Shi Yawei,
Zhang Qi,
Lin Ying,
Wang Shenming,
Zhang Yunjian
Publication year - 2019
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12751
Subject(s) - gestational diabetes , medicine , pregnancy , odds ratio , subclinical infection , obstetrics , thyroid function , cohort study , incidence (geometry) , cochrane library , meta analysis , gynecology , thyroid , gestation , genetics , physics , optics , biology
Background Subclinical hypothyroidism ( SCH ) and gestational diabetes mellitus ( GDM ) are common endocrine disorders that occur during pregnancy. Objective To determine whether the risk of GDM differs between pregnant women with normal thyroid function and those with SCH . Search strategy MEDLINE , EMBASE , the Cochrane Library, and Web of Science were searched for studies published in English from inception to March 1, 2017, using combinations of the search terms “thyroid dysfunction”, “thyroid diseases”, “subclinical hypothyroidism”, “hypothyroxinemia”, “thyrotropin”, “gestational diabetes”, “hyperglycemia in pregnancy”, and “adverse pregnancy outcomes”. Selection criteria We selected cohort studies that included pregnant women with SCH ; in which the outcome of interest was, or included, the incidence of GDM ; and that had data available for both the SCH and GDM groups. Studies were excluded if assisted reproductive technologies were used to achieve pregnancy; reviews, abstracts, and case reports were also excluded. Data collection and analysis Eleven studies were included in the analysis. Summary odds ratios ( OR s) for the risk of GDM were calculated. Main results SCH with positive antithyroid autoantibodies markedly increased GDM risk ( OR 3.22, 95% confidence interval 1.72–6.03, I 2 =55%). Conclusion SCH with positive antithyroid autoantibodies in pregnancy is associated with an increased risk of GDM .