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Maternal serum vitamin D levels and preterm delivery among low‐risk parturients in Lagos, Nigeria
Author(s) -
Oluwole Ayodeji A.,
Okunade Kehinde S.,
Okojie Osemen E.
Publication year - 2019
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12719
Subject(s) - medicine , odds ratio , obstetrics , confidence interval , vitamin d and neurology , vitamin d deficiency , pregnancy , cross sectional study , vitamin , pediatrics , genetics , pathology , biology
Objective To determine the association between low maternal vitamin D levels and preterm delivery among parturients in Lagos, Nigeria. Methods The present study was an analytical cross‐sectional study of women with preterm deliveries (defined as <37 weeks) and women with term deliveries (defined as ≥37 weeks) at the labor unit of Lagos University Teaching Hospital between December 1, 2015, and October 31, 2016. Relevant information was obtained via a proforma, and maternal venous samples were collected immediately after delivery. Serum 25‐hydroxy vitamin D was determined by a vitamin D enzyme‐linked immunoassay kit. Results The study enrolled 103 women in each group. The overall prevalence of vitamin D deficiency was 14.1% (29/206). 24 (23.3%) women with preterm delivery had low serum vitamin D (<30 ng/ mL ) as compared with only 5 (4.9%) women with term delivery ( P <0.001). Compared with normal serum vitamin D levels, low maternal vitamin D had an approximately nine‐fold higher likelihood of preterm delivery (adjusted odds ratio 9.41, 95% confidence interval 2.42–36.54; P <0.001). Conclusion The prevalence of serum vitamin D deficiency was higher among women with preterm delivery than among those with term delivery. The potential role of prenatal vitamin D supplementation in the prevention of preterm delivery should be further investigated.