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The association between Helicobacter pylori seropositivity and low birthweight in a Sudanese maternity hospital
Author(s) -
Mustafa Ahmed,
Bilal Naser E.,
Abass AwadElkareem,
Elhassan Elhassan M.,
Adam Ishag
Publication year - 2018
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12641
Subject(s) - medicine , umbilical cord , helicobacter pylori , obstetrics , pregnancy , confidence interval , cord blood , immunology , gastroenterology , biology , genetics
Objective To investigate the association between Helicobacter pylori seropositivity and low birthweight ( LBW ). Methods The present case–control study was conducted at a Sudanese maternity hospital from September 1 to December 30, 2015. Patients who delivered single neonates with LBW (>500 g but <2500 g) and the subsequent singleton delivery with birthweight of 2500–4000 g were included. A questionnaire was used to collect medical and obstetric data. The presence of malarial parasites in peripheral, placental, and umbilical cord samples was investigated using blood films. The presence of H. pylori immunoglobulin G (IgG) in maternal and umbilical cord serum samples was determined by enzyme‐linked immunosorbent assay. Results The study included 87 patients in each of the LBW and control groups. Maternal serum tested positive for H. pylori IgG among 66 (75.9%) and 48 (55.2%) patients in the LBW and control groups ( P =0.006); no malarial parasites were observed. Similarly, umbilical cord serum tested positive for H. pylori IgG among 66 (75.9%) and 34 (39.1%) patients in the LBW and control groups ( P <0.001). Maternal H. pylori IgG seropositivity ( OR 3.2, 95% CI 1.4–7.2; P =0.003) and umbilical cord H. pylori IgG seropositivity ( OR 2.4, 95% confidence interval 2.1–10.2; P <0.001) were significantly associated with LBW . Conclusion Seropositivity for H. pylori IgG was associated with LBW .