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Association of pre‐eclampsia with SOD 2 Ala16Val polymorphism among mother–father–infant triads
Author(s) -
Luo ZhongCheng,
Julien Pierre,
Wei ShuQin,
Audibert Francois,
Fraser William D.
Publication year - 2018
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12528
Subject(s) - single nucleotide polymorphism , odds ratio , snp , genotyping , eclampsia , medicine , confidence interval , genotype , genetics , pregnancy , gene , biology
Objective To determine whether pre‐eclampsia is associated with polymorphisms in superoxide dismutase ( SOD ) genes among mother–father–infant triads. Methods We did this follow‐up cohort study at 17 urban hospitals in Canada between October 1, 2008, and September 30, 2010. We recruited Canadian participants who had participated in the International Trial of Antioxidant Supplementation for the Prevention of Pre‐eclampsia. Saliva specimens were collected for DNA extraction. The SOD 1 +35A/C (rs2234694) and SOD 2 Ala16Val C/T (rs4880) single‐nucleotide polymorphisms ( SNP s) were genotyped. Results Dual presence of the SOD 2 Ala16Val TT variant among mother–father pairs (n = 657) was associated with an increased risk of pre‐eclampsia when compared with the absence of the TT variant among the mother–father pairs (7/48 [14.6%] vs 11/339 [3.2%]; adjusted odds ratio 6.80, 95% confidence interval 2.32–19.95; P< 0.001). By contrast, presence of a single T variant in mother–father pairs (16/270 [5.9%]) or mother–infant pairs (8/179 [4.5%]) was not associated with pre‐eclampsia. The SOD 1 +35A/C SNP was not associated with pre‐eclampsia. Conclusion The SOD 2 Ala16Val SNP might be involved in paternal influence on the maternal predisposition to pre‐eclampsia. Genotyping of mother–father pairs could be a promising strategy to identify pre‐eclampsia genes.