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Evaluation of biochemical, endocrine, and metabolic biomarkers for the early diagnosis of polycystic ovary syndrome among non‐obese Saudi women
Author(s) -
Daghestani Maha H.
Publication year - 2018
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12527
Subject(s) - medicine , polycystic ovary , endocrinology , luteinizing hormone , sex hormone binding globulin , waist , lipid profile , endocrine system , metabolic syndrome , insulin resistance , free androgen index , waist–hip ratio , anthropometry , testosterone (patch) , insulin , physiology , obesity , hormone , cholesterol , androgen
Objective To investigate the potential of selected biochemical, endocrine, and metabolic biomarkers for early diagnosis of polycystic ovary syndrome ( PCOS ) among non‐obese women. Methods A prospective observational cross‐sectional study was conducted at three medical centers in Makkah, Saudi Arabia, between July 15 and September 20, 2017. Eligible participants were non‐obese women diagnosed with PCOS according to the Rotterdam criteria (n=44) and non‐obese normo‐ovulatory women without signs of PCOS (control group; n=44). Anthropometric variables related to metabolic profile were determined. Laboratory measures were assessed using fasting blood samples. Results Waist circumference and waist‐to‐hip ratio were increased among women with PCOS (both P ˂0.001). When compared with the control group, patients in the PCOS group exhibited increases in cholesterol (13.8%), triglycerides (36.6%), low‐density lipoprotein (73.2%), fasting glucose (9.2%), fasting insulin (49.4%), luteinizing‐hormone/follicle‐stimulating‐hormone ratio (205.3%), 17β‐estradiol (39.2%), testosterone (202.3%), and vascular endothelial growth factor (241.7%) (all P <0.001); and decreases in high‐density lipoprotein (−25.3%), progesterone (−7.4%), and sex hormone‐binding globulin (−54.0%) (all P <0.001). Vitamin D ( P =0.095) and Kisspeptin ( P =0.944) levels did not differ between the groups. Conclusion Various parameters could potentially be used as biomarkers to assess risk of PCOS , even among symptom‐free non‐obese women.