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Endometrial neoplasia in reproductive‐aged Thai women with polycystic ovary syndrome
Author(s) -
Indhavivadhana Suchada,
Rattanachaiyat Manee,
Wongwananuruk Thanyarat,
Techatraisak Kitirat,
Rayasawath Nana,
Dangrat Chongdee
Publication year - 2018
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12522
Subject(s) - medicine , polycystic ovary , endometrial cancer , gynecology , insulin resistance , body mass index , endometrium , obstetrics , insulin , cancer
Objective To determine the risk of endometrial neoplasia in relation to endometrial thickness and to evaluate factors influencing endometrial thickness in reproductive‐aged Thai women with polycystic ovary syndrome ( PCOS ). Methods The present cross‐sectional study was done at the Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, between October 1, 2010, and January 31, 2013. We recruited women (aged ≥18 years) with PCOS diagnosed according to the revised 2003 Rotterdam criteria. Data were collected for physical examinations, pelvic ultrasonography, hormonal profiles, and carbohydrate metabolic profiles. Endometrial tissue was obtained using a disposable endometrial‐suctioning device. Results The final analysis included 122 women. Six (4.9%) patients had endometrial neoplasia. All six women had an endometrial thickness of 7 mm or more, representing a risk of 8.7% (6/69) in this group. The endometrial thickness was significantly but weakly associated with body mass index ( r =0.227, P =0.012), 2‐hour blood glucose ( r =0.323, P =0.001), fasting glucose to insulin ratio ( r =0.185, P =0.042), homeostatic model assessment of insulin resistance ( r =0.183, P =0.044), and free testosterone ( r =0.236, P =0.009). No categorical risk factors for an endometrial thickness of 7 mm or more were identified. Conclusion Thai women with PCOS and a thick endometrium (≥7 mm) had an 8.7% risk of endometrial neoplasia. Invasive endometrial surveillance for the prevention of endometrial cancer is recommended in these women.