Premium
Selenium deficiency and pregnancy outcome in pregnant women with HIV in Lagos, Nigeria
Author(s) -
Okunade Kehinde S.,
Olowoselu Olusola F.,
Osanyin Gbemisola E.,
JohnOlabode Sarah,
Akanmu Sulaimon A.,
Anorlu Rose I.
Publication year - 2018
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12508
Subject(s) - medicine , pregnancy , odds ratio , confidence interval , obstetrics , cross sectional study , selenium deficiency , selenium , genetics , catalase , oxidative stress , materials science , pathology , glutathione peroxidase , metallurgy , biology
Objective To investigate the prevalence of maternal selenium deficiency and its effects on pregnancy outcomes in pregnant women with HIV in Lagos, Nigeria. Methods The present descriptive cross‐sectional study enrolled women aged 15–49 years with HIV who were at 14–26 weeks of a singleton pregnancy and were attending Lagos University Teaching Hospital, Lagos, Nigeria, between August 1, 2016, and April 30, 2017. Participants were selected by consecutive sampling and baseline data were collected through interviews. Venous blood samples were obtained to measure selenium concentrations, and associations between low maternal selenium concentrations (defined as <0.89 μmol/L) and pregnancy outcomes were examined using bivariate and multivariate analysis. Results The final analysis included 113 patients; selenium deficiency was recorded in 23 (20.4%) patients. Women with selenium deficiency had an approximately eight‐fold higher risk of preterm delivery (adjusted odds ratio 7.61, 95% confidence interval 4.37–18.89; P =0.031) and of delivering a term neonate with a low delivery weight (adjusted odds ratio 8.11, 95% confidence interval 3.27–17.22; P =0.012), compared with women with a normal selenium concentration. Conclusion The prevalence of selenium deficiency among pregnant women with HIV in Lagos was relatively high. The significant associations observed between maternal selenium deficiency and adverse pregnancy outcomes could have implications for the future management of HIV in pregnancy.