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Increased serum levels of high mobility group protein B1 and calprotectin in pre‐eclampsia
Author(s) -
Li Jinfeng,
Huang Lifeng,
Wang Shuzhen,
Zhang Zhenyu
Publication year - 2018
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12491
Subject(s) - medicine , eclampsia , calprotectin , pregnancy , high mobility group , gastroenterology , endocrinology , biochemistry , genetics , disease , gene , inflammatory bowel disease , biology , chemistry
Objective To determine whether women with pre‐eclampsia have serum levels of biomarkers indicative of an elevated systemic inflammatory response. Method The present cross‐sectional study was conducted among pregnant women either with pre‐eclampsia or without pre‐eclampsia who were recruited at a single Chinese hospital between August 1, 2016, and April 30, 2017. Eligible women had no history of acute or chronic inflammation. Serum concentrations of high mobility group protein B1 ( HMG ‐1), calprotectin, and Toll‐like receptor 4 ( TLR 4) were measured and compared. Results There were 55 patients included (25 with pre‐eclampsia and 30 without). The mean serum concentration of calprotectin was 2656.76 ± 1724.56 μg/L in the pre‐eclampsia group versus 1877.33 ± 905.69 μg/L in the control group ( P =0.036). Among patients with pre‐eclampsia, elevated calprotectin levels were positively associated with the duration of hypertension in pregnancy ( P =0.031) and were negatively associated with pregnancy duration at delivery ( P =0.035). The mean serum concentration of HMG ‐1 was 72.48 ± 27.57 μg/L in the pre‐eclampsia group versus 57.57 ± 20.07 μg/L in the control group ( P =0.017). The mean serum concentration of TLR 4 was 22.83 ± 8.46 μg/L in the pre‐eclampsia group versus 18.83 ± 6.79 μg/L in the control group ( P =0.057). Conclusion Elevated levels of HMG ‐1 and calprotectin could reflect an excessive systemic inflammatory response in pre‐eclampsia.