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Association between induced abortion history and later in vitro fertilization outcomes
Author(s) -
Wang Yao,
Sun Yun,
Di Wen,
Kuang Yanping,
Xu Bing
Publication year - 2018
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12481
Subject(s) - medicine , abortion , obstetrics , in vitro fertilisation , pregnancy , gynecology , retrospective cohort study , medical abortion , medical history , fertility , cohort study , population , misoprostol , surgery , genetics , environmental health , biology
Objective To establish an effective and safe clinical fertility strategy by investigating the relationship between abortion history and pregnancy outcomes of in vitro fertilization ( IVF ) treatment. Methods In the present retrospective cohort study, data from IVF treatment cycles performed at a reproductive center in China between October 1, 2014, and October 31, 2015, were assessed. Outcomes were compared between women with a history of induced abortion and those without. Results There were 1532 IVF treatment cycles included; 454 patients had a history of induced abortion and 1078 did not. The spontaneous abortion rate was significantly higher (30/170 [17.6%] vs 41/420 [9.8%]; P =0.002) and the endometrium was significantly thinner (8.8 ± 1.8 vs 9.7 ± 1.8 cm; P =0.001) among patients with a history of induced abortion compared with those without. In a subgroup analysis of patients with a history of induced abortion, women who had undergone surgical abortions had a lower live delivery rate compared with medical abortions (29/76 [38%] vs 101/378 [27%]; P =0.039). Further, women who had a history of more than two surgical abortions had lower live delivery and clinical pregnancy rates (both P <0.05). Conclusion A history of induced abortion was associated with worse IVF outcomes, especially a history of more than two surgical abortions.