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Comparison of dual trigger with combination Gn RH agonist and hCG versus hCG alone trigger of oocyte maturation for normal ovarian responders
Author(s) -
Zhou Xingyu,
Guo Pingping,
Chen Xin,
Ye Desheng,
Liu Yudong,
Chen Shiling
Publication year - 2018
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12457
Subject(s) - medicine , intracytoplasmic sperm injection , human chorionic gonadotropin , agonist , andrology , oocyte , in vitro fertilisation , gonadotropin releasing hormone , human fertilization , hormone antagonist , antagonist , gonadotropin releasing hormone agonist , endocrinology , pregnancy , hormone , embryo , receptor , biology , luteinizing hormone , genetics , microbiology and biotechnology , anatomy
Abstract Objective To investigate whether dual triggering of oocyte maturation with a gonadotropin‐releasing hormone (Gn RH ) agonist and standard dose of human chorionic gonadotropin ( hCG ) can improve clinical outcomes for normal ovarian responders in Gn RH antagonist cycles. Methods The present retrospective cohort study included women aged up to 40 years with normal ovarian response who underwent in vitro fertilization and/or intracytoplasmic sperm injection under the Gn RH antagonist protocol at Nanfang Hospital, China, between January 1 and December 31, 2015. Patients were grouped by whether oocyte maturation was triggered with Gn RH agonist plus 5000–10 000 IU of hCG (dual trigger) or hCG alone. The primary outcome was live delivery rate. Results There were 325 women included; 224 in the dual trigger group and 101 in the hCG alone group. The live delivery rate did not differ significantly between the groups ( P =0.083). The mean number of retrieved oocytes was similar in the two groups ( P =0.719), but the mean number of two‐pronuclear embryos ( P =0.004), the mean number of embryos available ( P =0.001), and the mean number of high‐quality embryos ( P =0.011) was higher in the dual trigger group. Conclusions Dual trigger of oocyte maturation was not associated with any change in the live delivery rate but was associated with improvements in the quantity and quality of embryos; it could optimize pregnancy outcomes for normal ovarian responders.