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Urine test for HPV genotypes as a predictor of precancerous cervical lesions and for cervical cancer screening
Author(s) -
Maged Ahmed M.,
Saad Hany,
Salah Emad,
Meshaal Hadeer,
AbdElbar Mostafa,
Omran Eman,
Eldaly Ashraf
Publication year - 2018
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12453
Subject(s) - medicine , urine , cervical cancer , cervix , confidence interval , cytology , prospective cohort study , gynecology , cancer , pathology
Objective To assess the sensitivity of a urine test for high‐risk HPV DNA genotypes in the detection of high‐grade squamous intra‐epithelial lesion ( HSIL ) and its correlation with pathologic precancerous lesions. Methods The present prospective cross‐sectional study included women referred to Kasr AlAiny Medical School, Cairo, Egypt, for cervical smear anomalies, a history of cervical smear anomalies, or for suspicious cervix between May 1, 2015, and April 30, 2017. Paired urine tests and cervical smears were performed. HPV DNA was detected in urine using polymerase chain reaction and cervical smears were performed with a cervical spatula and a cytobrush. Agreement between urine test results and pathology was examined. Results In total, 1375 women were included. Urine test for high‐risk HPV DNA demonstrated 97.8% (95% confidence interval [ CI ] 92.1%–99.7%) sensitivity and 100% (95% CI 99.7%–100.0%) specificity for HSIL . Overall, 87 women had a positive urine test for high‐risk HPV ; of these, 82 (94.3%, 95% CI 87.1%–98.1%) had pathologic findings of cervical intra‐epithelial neoplasia 2 or 3 ( CIN 2/3). Similarly, 89 women had HSIL cytology; again, 82 had CIN 2/3 (92.1%; 95% CI , 84.3%–96.4%). Conclusion There was good agreement between a positive urine test for high‐risk HPV DNA genotypes and pathologic findings of CIN 2/3.