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Randomized cross‐over trial comparing the diagnosis of gestational diabetes by oral glucose tolerance test and a designed breakfast glucose profile
Author(s) -
Marais Colin,
Hall David R.,
Wyk Lourentia,
Conradie Magda
Publication year - 2018
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12427
Subject(s) - medicine , gestational diabetes , diabetes mellitus , randomized controlled trial , obstetrics , venous blood , glucose test , gestation , glucose tolerance test , fasting glucose , pregnancy , endocrinology , insulin resistance , genetics , biology
Objective To compare a glucose test based on a standardized, designed breakfast to the 75‐g oral glucose tolerance test ( OGTT ), comparing venous and capillary glucose values for the diagnosis of gestational diabetes mellitus ( GDM ). Methods The present prospective, randomized, cross‐over trial enrolled patients at high risk of developing GDM who were attending the High‐Risk Antenatal Clinic of Tygerberg Hospital, Cape Town, South Africa, between March 1 and December 31, 2015. Patients were randomized to initial testing with either the OGTT or a designed breakfast glucose profile ( DBGP ) glucose test before the alternate test was performed 1 week later; no dietary or other interventions were applied in the intervening period. Venous and capillary fasting and 2‐hour glucose values were measured and were compared between the OGTT and DBGP , and between OGTT and laboratory venous samples. Results There were 51 patients included in the study. The fasting and 2‐hour capillary glucose values from the OGTT correlated significantly with the laboratory venous samples ( P <0.001 at both time intervals). The 2‐hour capillary glucose values from the DBGP demonstrated a satisfactory correlation with those from the OGTT ( P <0.001). Conclusions The DBGP provided a sufficiently accurate alternate test for the diagnosis of GDM ; it warrants further investigation.

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