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Vaginal discharge concentrations of β‐human chorionic gonadotropin, creatinine, and urea for the diagnosis of premature rupture of membranes
Author(s) -
Bouzari Zinatossadat,
Shahhosseini Roza,
Mohammadnetaj Meadeh,
Barat Shahnaz,
Yazdani Shahla,
HajianTilaki Karimollah
Publication year - 2018
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12414
Subject(s) - medicine , prom , creatinine , human chorionic gonadotropin , urology , vaginal discharge , premature rupture of membranes , gonadotropin , urea , gynecology , renal function , obstetrics , pregnancy , endocrinology , gestation , hormone , chemistry , biology , genetics , organic chemistry
Objective To determine the diagnostic value of vaginal discharge concentrations of β human chorionic gonadotropin (β‐ hCG ), creatinine, and urea to identify premature rupture of membranes ( PROM ). Methods An observational cross‐sectional study was conducted between 12 June, 2014, and 11 June, 2015, among 120 women who were admitted to an Iranian hospital at 28–41 weeks of pregnancy. Women with positive pooling and nitrazine test results were assigned to the PROM group (n=60), whereas those with negative test results were assigned to the control group (n=60). Samples of vaginal discharge were obtained. Results Mean concentrations of β‐ hCG , urea, and creatinine were all higher in the PROM group than in the control group (all P =0.001). The diagnostic accuracies as defined by area under the curve for creatinine, urea, and β‐ hCG were 0.891, 0.895, and 0.908, respectively. The corresponding optimal cutoff values were 20.33 μmol/L, 0.94 mmol/L, and 39.5 IU /L, respectively. Conclusion The vaginal discharge concentrations of all three markers exhibited favorable predictive value for the diagnosis of PROM ; however, β‐ hCG showed greater diagnostic accuracy than either urea or creatinine.