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Cross‐sectional study of anal intraepithelial lesions in women with cervical neoplasia without HIV
Author(s) -
Heráclio Sandra A.,
Souza Alex S.R.,
Souza Paulo R.E.,
Katz Leila,
Lima Junior Sergio F.,
Amorim Melania M.R.
Publication year - 2018
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12367
Subject(s) - medicine , cervical intraepithelial neoplasia , cross sectional study , outpatient clinic , intraepithelial neoplasia , gynecology , cytology , anal cancer , multivariate analysis , gastroenterology , cervical cancer , pathology , cancer , prostate
Objective To evaluate the prevalence of anal intraepithelial lesions and associated risk factors in women with cervical neoplasia. Methods The present cross‐sectional study enrolled patients with intraepithelial or invasive cervical neoplasia who had been referred to the lower genital tract pathology outpatient department of the Instituto de Medicina Integral Prof. Fernando Figueira, Recife, Brazil, between December 1, 2008, and December 31, 2009; patients with HIV infections were excluded. All participants underwent anal cytology and high‐resolution anoscopy; sociodemographic and clinical risk factors were identified using multivariate analysis. Results There were 324 patients included and 37 (11.4%) had anal intraepithelial neoplasia. Factors associated with anal intraepithelial neoplasia in the multivariate analysis were being older than 35 years of age ( P= 0.002), having completed no more than 4 years of education ( P= 0.012), anomalous anal cytology ( P= 0.003), and anomalous high‐resolution anoscopy findings ( P< 0.001); subclinical HPV lesions on vulvoscopy ( P= 0.057) were not associated with anal intraepithelial neoplasia. Conclusion The prevalence of anal intraepithelial neoplasia was high among patients with cervical neoplasia who did not have HIV , particularly patients older than 35 years.