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Randomized trial of combined cabergoline and coasting in preventing ovarian hyperstimulation syndrome during in vitro fertilization/intracytoplasmic sperm injection cycles
Author(s) -
Bassiouny Yasmin A.,
Dakhly Dina M.R.,
Bayoumi Yomna A.,
Salaheldin Noha M.,
Gouda Hisham M.,
Hassan Ayman A.
Publication year - 2018
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12360
Subject(s) - cabergoline , ovarian hyperstimulation syndrome , intracytoplasmic sperm injection , in vitro fertilisation , medicine , gynecology , randomized controlled trial , human fertilization , pregnancy , biology , surgery , anatomy , hormone , prolactin , genetics
Abstract Objective To assess the efficacy of coasting alone, cabergoline alone, or combining both interventions for preventing ovarian hyperstimulation syndrome ( OHSS ) among high‐risk patients undergoing in vitro fertilization/intracytoplasmic sperm injection ( IVF / ICSI ) treatment cycles. Methods The present randomized controlled trial was conducted at the IVF unit of a university hospital in Cairo between October 28, 2013, and July 31, 2015. Patients undergoing IVF / ICSI considered at risk of OHSS were randomly allocated to coasting, cabergoline, or combined coasting and cabergoline. The primary outcome was the rate and degree of symptomatically assessed OHSS . Data were analyzed on a per‐protocol basis. Results There were 100 patients recruited to each group. The occurrence of early OHSS was lowest in the combination group compared with the other groups ( P= 0.002). Conclusion Combining coasting and cabergoline was associated with a lower OHSS rate compared with either therapy alone. ClinicalTrials.gov NCT01984320