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Neonatal delivery weight and risk of future maternal diabetes
Author(s) -
Stuart Andrea E.,
AmerWåhlin Isis,
Källen Karin B.M.
Publication year - 2018
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12337
Subject(s) - medicine , odds ratio , hazard ratio , gestational diabetes , type 2 diabetes , obstetrics , pregnancy , risk factor , confidence interval , gestational age , birth weight , diabetes mellitus , type 1 diabetes , pediatrics , gestation , endocrinology , biology , genetics
Objective To investigate associations between neonatal delivery weight and future risk of maternal type 1 or type 2 diabetes. Methods Data included in the Swedish Medical Birth Registry and Swedish National Diabetes Registry were merged to include all women born during 1930–1989; patients with pre‐existing diabetes or gestational diabetes were excluded. Cox regression analyses were performed to identify associations between the neonatal delivery weight from the most recent pregnancy and later occurrence of diabetes. Results There were 1 873 440 patients included in the analyses. An increased risk of type 1 (hazard ratio 3.60, 95% confidence interval [ CI ] 3.23–4.01) or type 2 diabetes (hazard ratio 2.77, 95% CI 2.68–2.87) was observed among patients who had a large for gestational age neonate compared with patients who had neonates within one standard definition of the mean weight for gestational age; the odds of developing type 1 (odds ratio 10.27, 95% CI 7.37–14.31) or type 2 diabetes (odds ratio 8.50, 95% CI 6.01–12.02) within 1 year of delivery was also increased compared with patients who had a neonate within one standard deviation of the mean weight for gestational age. Conclusions Delivering a large for gestational age neonate was a potent risk factor for the later development of maternal type 1 or type 2 diabetes.