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A systematic review and meta‐analysis of nonpharmacological adjuvant interventions for patients undergoing assisted reproductive technology treatment
Author(s) -
Chu Kun,
Zhang Qing,
Han Hedong,
Xu Chen,
Pang Wenjuan,
Ma Yan,
Sun Ningxia,
Li Wen
Publication year - 2017
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12310
Subject(s) - medicine , psychological intervention , randomized controlled trial , meta analysis , anxiety , strictly standardized mean difference , physical therapy , assisted reproductive technology , confidence interval , distress , infertility , medline , pregnancy , depression (economics) , clinical psychology , psychiatry , surgery , biology , political science , law , genetics , macroeconomics , economics
Background Assisted reproductive technology ( ART ) is not always successful, yet places a high psychological burden on individuals. Objectives To assess whether nonpharmacological adjuvant interventions could improve outcomes among patients receiving ART . Search strategy Electronic databases were searched from inception to March 2017, using keywords such as “fertility treatment,” “emotional distress,” and “clinical pregnancy.” Selection criteria Reports of randomized controlled trials investigating the impact of nonpharmacological interventions on emotional disorders and the pregnancy rate in patients receiving ART published in any language were included. Data collection and analysis Data were extracted into a predesigned form. Psychological ratings were pooled using standardized mean differences ( SMD s). Heterogeneity was assessed. The primary outcome measures were psychological ratings at baseline and after intervention. Main results Overall, 34 randomized controlled trials, with a total of 7213 patients, met the inclusion criteria. Nonpharmacological interventions reduced anxiety when compared with control interventions ( SMD 0.25, 95% confidence interval 0.08–0.42; I 2 =85%), but they had no significant effects on depression and infertility distress. Conclusions Nonpharmacological interventions could improve the psychological outcomes of patients undergoing ART treatment.