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Accuracy of 50‐g glucose challenge test to detect International Association of Diabetes and Pregnancy Study Groups criteria‐defined hyperglycemia
Author(s) -
Olagbuji Biodun N.,
Aderoba Adeniyi K.,
Kayode Oluwatosin O.,
Awe Christianah O.,
Akintan Adesina L.,
Olagbuji Yetunde W.
Publication year - 2017
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12304
Subject(s) - medicine , confidence interval , pregnancy , diabetes mellitus , prospective cohort study , obstetrics , cohort study , endocrinology , genetics , biology
Objectives To determine the accuracy of the 50‐g glucose challenge test ( GCT ) in detecting hyperglycemia in pregnancy ( HIP ) across a range of glucose thresholds relative to the International Association of Diabetes and Pregnancy Study Groups diagnostic criteria, and to determine the accuracy of the 50‐g GCT among patients with different risk status. Methods The present prospective cohort study included women aged 18–45 years at 24–31 +6 weeks of pregnancy who presented at the Mother and Child Hospital, Akure, Nigeria, between September 1, 2015, and February 29, 2016. Patients underwent the 50‐g GCT followed by the 75‐g oral glucose tolerance test ( OGTT ). The accuracy of different 50‐g GCT thresholds in diagnosing HIP was assessed based on International Association of Diabetes and Pregnancy Study Groups diagnostic criteria, with the 75‐g OGTT used as a clinical reference standard. Results Of 280 patients enrolled, 46 (16.4%) had HIP . The sensitivity of the 50‐g GCT to detect HIP decreased from 47.8% (95% confidence interval [ CI ], 32.9–63.1) at a 7.2‐mmol/L threshold to 32.6% (95% CI , 19.5–48.0) at a 8.0‐mmol/L threshold; the specificity improved from 84.2% (95% CI , 78.9–88.6) to 95.3% (95% CI , 91.7–97.6), respectively. Conclusion The 50‐g GCT performed poorly compared with the 75‐g OGTT for detecting HIP . It appears to be an unsuitable replacement for the 75‐g OGTT .