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Assessment of serum β‐ hCG and lipid profile in early second trimester as predictors of hypertensive disorders of pregnancy
Author(s) -
Revankar Vijaya M.,
Narmada Lavu
Publication year - 2017
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12225
Subject(s) - medicine , dyslipidemia , lipid profile , pregnancy , human chorionic gonadotropin , receiver operating characteristic , venous blood , prospective cohort study , second trimester , obstetrics , first trimester , gynecology , endocrinology , gastroenterology , fetus , hormone , cholesterol , biology , genetics , obesity
Objective To assess and compare the ability of serum β‐human chorionic gonadotropin (β‐ hCG ) and serum lipid profile in early second trimester as predictors of hypertensive disorders of pregnancy. Methods The present hospital‐based prospective study was conducted between November 24, 2012, and April 30, 2014, at a tertiary hospital in Mangalore, India. Women of any parity with a pregnancy of 14–20 weeks were included. Venous blood (3 mL ) was collected, and serum β‐ hCG and lipid profile were estimated by enzyme‐linked immunosorbent assay and an enzymatic colorimetric test with lipid clearing factor, respectively. A cutoff value of β‐ hCG for predicting hypertensive disorders was obtained by receiver operating curve analysis. Results Serum β‐ hCG was significantly higher among women who subsequently developed hypertension (71 142 IU /L [n=27]) than among those who did not (20 541 IU /L [n=137]; P< 0.001). The sensitivity and specificity of serum β‐ hCG to predict hypertension were 92.6% and 94.9% respectively. The positive and negative predictive values were 78.1% and 98.5%, respectively. Conclusion Serum β‐ hCG might be used as a predictor of hypertensive disorders that complicate pregnancy. Dyslipidemia was not found to be a useful marker.