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RETRACTED: A randomized trial of local endometrial injury during ovulation induction cycles
Author(s) -
Helmy Medhat E.E.,
Maher Mohammad A.,
Elkhouly Nabih I.,
Ramzy Mahmoud
Publication year - 2017
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/ijgo.12178
Subject(s) - medicine , pregnancy , unexplained infertility , pregnancy rate , gynecology , obstetrics , randomized controlled trial , infertility , clomifene , ovulation , ovulation induction , abortion , adverse effect , hormone , genetics , biology
Abstract Objective To investigate the effect of endometrial injury on pregnancy outcomes among infertile women taking clomifene citrate. Methods A prospective randomized trial was undertaken at an Egyptian hospital between January 26, 2015, and July 17, 2016. Eligible women (≥1 year primary/secondary/unexplained infertility, aged 20–35 years, day‐2 follicle‐stimulating hormone <12 IU /L, normal prolactin/thyroid function/uterine cavity, ≥1 patent tube, male partner with normal semen count and motility, 3 cycles of clomifene citrate without success) were randomly allocated (1:1) using computer‐generated numbers into intervention (received endometrial injury on cycle day 15–24) or control groups (sham procedure). Women began ovulation induction on days 3–5 of the following cycle. Participants and investigators were not masked to group assignment. The primary outcomes were clinical pregnancy, spontaneous abortion, and multiple pregnancy rates. Women who completed follow‐up were included in analyses. Results The intervention group included 52 women and the control group 53 women. The clinical pregnancy rate was significantly higher in the intervention group (37% [n=19]) than in the control group (13% [n=7]; P =0.006). No differences between the intervention and control groups were noted for spontaneous abortion rate (11% [2/19] vs 29% [2/7]; P =0.287) or multiple pregnancy rate (11% [2/19] vs 14% [1/7]; P =0.790). No adverse effects were reported. Conclusion Endometrial injury before ovulation induction could improve chances of pregnancy and its outcomes. ClinicalTrials.gov NCT 02345837.